HCT116 Cells Cytotoxic Response to Multifuctionalized 5- Fluorouracil MWCNTs Conjugates In Colorectal Cancer

Nanomaterials are the foundations of Nanotechnology, which measured in nanoscales, Carbon nanotubes one interesting nanomaterials, studied for over 25 years because their superlative properties such as high surface area, electrical and thermal conductivity, biocompatibility, flexibility, resistance to corrosion nanosize. According research, carbon applied sensing, water treatment, drug delivery, mainly used deliver anticancer drugs. In our work, functionalization multi walled done by covalent non-covalent functionation methods, showed better dispersing efficiency aqueous medium compatible with biological systems damaging crystal lattice nanotubes. Non helps derivatized active compounds, adsorption or attachment various molecules antibodies, subsequently targeting site produce therapeutic effects. Different formulations prepared functionalized MWCNTs multiple binding antibodies prepare 5-Fluorouracil complexes. The Cytotoxicity assay was carried out obtained new analyze effect all on HCT116 cell line. percentage death determined based viability cells appropriate vehicle controls. this study, we report successful functionalization, 5 Fluorouracil, MWCNTs, development novel delivery system. Functionalized MWCNTs-5-Fluorouracil composite at concentration above 2.5 µg/mL exhibited ≥ 50% cytotoxicity post normalization compound control negate precipitation observed compound. All precipitations indicating antitumor activity biocompatibility.